I thought you might get some perspective by reviewing the Stylus list of independent stores they chose as the best. Many are larger stores that have spawned small franchises with a few stores, but most on the lists started as very small stores and in some cases, have moved location.
http://www.stylusmagazine.com/articl...orite-shop.htm
Part I: East
Part II: South
Part III: Midwest
Part IV: West
Part V: International